Persistence of group B Streptococcus vaginal colonization and prevalence of hypervirulent CC-17 clone correlate with the country of birth: a prospective 3-month follow-up cohort study.
Céline PlainvertOlivia AnselemCaroline JoubrelValérie MarcouAmiel FalloukhAmandine FrigoFatma Magdoud El AlaouiPierre-Yves AncelPierre Henri JarreauLaurent MandelbrotFrançois GoffinetClaire PoyartAsmaa TaziPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2020)
To identify factors associated with vaginal colonization and persistence by group B Streptococcus (GBS) and by the hypervirulent neonatal CC-17 clone in late pregnancy and after delivery, a multicentre prospective observational cohort with 3-month follow-up was established in two university hospitals, Paris area, France. Pregnant women were recruited when antenatal screening for GBS vaginal colonization at 34-38 weeks of gestational age was positive. Vaginal samples were analysed by conventional culture methods at antenatal screening, delivery, and 21 and 60 days following delivery. Identification of the hypervirulent neonatal GBS CC-17 was performed. Colonization was defined as persistent when all vaginal samples were positive for GBS. A total of 754 women were included. GBS vaginal colonization was persistent in 63% of the cases (95% CI 59%-67%). Persistent colonization was more likely in women born in Sub-Saharan Africa compared with women born in France (OR = 1.88, 95% CI 1.05-3.52), and GBS CC-17 was overrepresented in women born in Sub-Saharan Africa (OR = 2.09, 95% CI 1.20-3.57). Women born in Sub-Saharan Africa are at higher risk for GBS vaginal persistence than women born in France. This observation correlates with an increased prevalence of the hypervirulent GBS CC-17 in the former group, which likely reflect variations linked to ethnicity and vaginal community-state types and might account for the increased susceptibility of black neonates to GBS infections.
Keyphrases
- gestational age
- preterm birth
- pregnancy outcomes
- pregnant women
- polycystic ovary syndrome
- birth weight
- low birth weight
- cervical cancer screening
- healthcare
- mental health
- type diabetes
- preterm infants
- risk factors
- candida albicans
- insulin resistance
- metabolic syndrome
- escherichia coli
- body mass index
- study protocol
- randomized controlled trial
- skeletal muscle
- pseudomonas aeruginosa
- staphylococcus aureus
- clinical trial
- cystic fibrosis