Pill Burden: A Major Barrier to HAART Adherence and Fixed Dose Combinations (FDCS) as its Solution - A Mini-Review.
Mugisa SimonSsebaduka DerrickSreya KosanamRajeshwari PasupulaPublished in: Current HIV research (2024)
HIV/ AIDS is a global pandemic and one of the most challenging; With no cure of the disease, various therapies available in form of regimens as Highly Active Anti-Retroviral Therapy (HAART) are the only way to manage the disease. Adherence to HAART is the most vital factor to ensure medication success and virologic suppression. However, adherence is faced with several barriers including adverse effects of Anti-Retroviral Therapy (ART) drugs, complexity of ART, social, cultural factors, and pill burden among others. Fixed Dose Combinations (FDC's) concept has been a well-recognised improvement in pharmacotherapy for treatment of a variety of chronic maladies like hypertension, diabetes, HIV/AIDS, and several FDC products consisting of HIV drugs are approved. This writing reviews the concept of adherence to ART, its barriers while stressing pill burden as a significant one which we suggest would be solved by use Fixed Dose Combinations (FDCs). </p>.
Keyphrases
- hiv aids
- antiretroviral therapy
- hiv infected patients
- hiv infected
- human immunodeficiency virus
- hiv positive
- glycemic control
- type diabetes
- healthcare
- blood pressure
- coronavirus disease
- cardiovascular disease
- risk factors
- systematic review
- mental health
- adverse drug
- randomized controlled trial
- insulin resistance
- metabolic syndrome
- replacement therapy
- hepatitis c virus
- cell therapy
- skeletal muscle
- electronic health record