Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5.
Hao-Yu DongYuan WangXiao-Yu ZhangMeng ZhangLong-He YangZheng-Biao ZouYou LiMing-Min XieXian-Wen YangBin WangPublished in: Chemistry & biodiversity (2024)
Three new C 10 and C 12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC 50 value of 120.3 nM.
Keyphrases
- lps induced
- high resolution
- inflammatory response
- nitric oxide
- fatty acid
- induced apoptosis
- cell cycle arrest
- electronic health record
- photodynamic therapy
- big data
- cell death
- endoplasmic reticulum stress
- high speed
- nitric oxide synthase
- signaling pathway
- data analysis
- mass spectrometry
- solid state
- genetic diversity
- cell proliferation
- pi k akt