Associations between perceived discrimination experiences, treatment adherence self-efficacy, and depressive symptoms among people living with HIV in the Southern United States.

This study examined associations between perceived discrimination, treatment adherence self-efficacy, and depressive symptoms among people living with HIV (PLHIV) in the Southern United States. Cross-sectional survey data were collected from 402 PLHIV who self-reported on interpersonal discrimination experiences based on HIV status, sexuality, gender, income, and living condition. Participants also reported on adherence self-efficacy and depressive symptoms. We employed K-means clustering to identify groups based on discrimination experiences, and logistic regressions to examine group differences on adherence self-efficacy and depressive symptoms. Results suggested three groups: a cluster with high perceived discrimination across all identities/conditions ( n  = 41; 11%; Cluster 1); a cluster with high perceived discrimination based on HIV status, income, and living condition ( n  = 49; 13%; Cluster 2); and a cluster with low perceived discrimination across all identities/conditions ( n  = 288; 76%; Cluster 3). Compared to Cluster 3, Cluster 1 and 2 had 2.22 times ( p  = .037) and 3.98 times ( p <.001) greater odds of reporting depressive symptoms. Compared to Cluster 3, Cluster 2 had 3.40 times ( p  = .003) greater odds of reporting lower adherence self-efficacy. Findings demonstrate the need for individual-level support for PLHIV with discrimination histories, and broader efforts to end the stigma, discrimination, and marginalization of PLHIV based on HIV status and other characteristics.