Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP): The contribution of orexin.

Shruthi H IyerAnkita AggarwalTed J WarrenJodi HallgrenPeter W AbelTimothy A Simeone Kristina A Simeone

Published in: Epilepsia (2020)

High-risk KO mice have a unique cardiorespiratory phenotype that is characterized by progressive changes in five interdependent endpoints. Blocking of orexin receptors attenuates some of these endpoints and increases longevity, supporting the notion that windows of opportunity for intervention exist in this preclinical SUDEP model.

Keyphrases

multiple sclerosis
body composition
randomized controlled trial
high intensity
high fat diet induced
oxidative stress
cell therapy
type diabetes
stem cells
image quality
drosophila melanogaster
computed tomography
insulin resistance
skeletal muscle
dual energy