Role of Bβ1 overexpression in the pathogenesis of SCA12.

Chengqian ZhouFan TangTao DongHans B LiuLeon DengRussell L MargolisPan P Li

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

The SCA12 mutation leads to overexpression of PPP2R2B Bβ1 and to expression of a protein containing a long polyserine tract; both these effects potentially contribute to SCA12 pathogenesis. © 2024 International Parkinson and Movement Disorder Society.

Keyphrases

cell proliferation
poor prognosis
transcription factor
binding protein
protein protein