Cancer-Causative Mutations Occurring in Early Embryogenesis.
Fresia ParejaRyan N PtashkinDavid N BrownFatemeh DerakhshanPier SelenicaEdaise M Da SilvaAndrea M GazzoArnaud Da Cruz PaulaKelsey E BreenRonglai ShenAntonio MarraAhmet ZehirRyma BenayedMichael F BergerOzge Ceyhan-BirsoySowmya JairamMargaret SheehanUtsav PatelYelena M KemelJacklyn Casanova-MurphyChristopher J SchwartzMahsa VahdatiniaElizabeth ComenLaetitia BorsuIsaac X PeiNadeem RiazDavid H AbramsonBritta WeigeltMichael F WalshAnna-Katerina HadjantonakisMarc LadanyiKenneth OffitZsofia K StadlerMark E RobsonJorge S Reis-FilhoDiana MandelkerPublished in: Cancer discovery (2022)
Here, we demonstrate that mosaic variants in CSGs arising in early embryogenesis contribute to the oncogenesis of seemingly sporadic cancers. These variants can be systematically detected through the analysis of tumor/normal sequencing data, and their detection may affect therapeutic decisions as well as prophylactic measures for patients and their offspring. See related commentary by Liggett and Sankaran, p. 889. This article is highlighted in the In This Issue feature, p. 873.
Keyphrases
- end stage renal disease
- copy number
- chronic kidney disease
- ejection fraction
- papillary thyroid
- type diabetes
- squamous cell carcinoma
- high fat diet
- late onset
- single cell
- gene expression
- patient reported outcomes
- young adults
- metabolic syndrome
- transcription factor
- real time pcr
- genome wide identification
- data analysis