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N -Fluorosulfonyl Guanidine: An Entry to N -Guanyl Sulfamides and Sulfamates.

Wei WangJingyuan LiLong XuJiajia Dong
Published in: Organic letters (2024)
Here, we present the straightforward synthesis of N -fluorosulfonyl guanidine ( 1 ) from two industrial feedstocks, guanidine hydrochloride and sulfuryl fluoride (SO 2 F 2 ), using SuFEx chemistry. Compound 1 exhibits excellent stability under ambient conditions and displays unique SuFEx reactivity toward amines and phenols to generate N -guanyl sulfamides and sulfamates that have rarely been accessed. Notably, water serves as an effective solvent in this process. Our protocol provides a reliable pathway for the synthesis and investigation of these novel guanidine-containing molecules.
Keyphrases
  • air pollution
  • randomized controlled trial
  • particulate matter
  • wastewater treatment
  • heavy metals
  • drinking water
  • ionic liquid