Integral bHLH factor regulation of cell cycle exit and RGC differentiation.
Kate A MaurerAngelica KowalchukFarnaz Shoja-TaheriNadean L BrownPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2018)
Our data support the hypothesis that Neurog2 acts at the top of a retinal bHLH transcription factor hierarchy. The combined expression levels of these downstream factors are sufficiently induced by ectopic Ascl1 to restore RGC genesis, highlighting the robustness of this gene network during retinal ganglion cell neurogenesis. Developmental Dynamics 247:965-975, 2018. © 2018 Wiley Periodicals, Inc.
Keyphrases
- transcription factor
- cell cycle
- genome wide identification
- cell proliferation
- poor prognosis
- dna binding
- single cell
- optical coherence tomography
- diabetic retinopathy
- electronic health record
- cell therapy
- genome wide
- copy number
- big data
- binding protein
- stem cells
- optic nerve
- dna methylation
- blood brain barrier
- brain injury
- genome wide analysis
- deep learning