Enhanced Ca 2+ -Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation.

Jordi Heijman Xiao-Bo Zhou Stefano Morotti Cristina E Molina Issam H Abu-TahaMarcel TekookThomas JespersenYiqiao ZhangShokoufeh DobrevAndreas BrodehlJan GummertMatthias KarckMarkus KamlerAli El-ArmoucheArnela SaljicEleonora GrandiStanley Nattel Dobromir Dobrev

Published in: Circulation research (2023)

, which promote reentry-stabilizing action potential duration shortening, suggest an important role for SK-channels in AF auto-promotion and provide a rationale for pursuing the antiarrhythmic effects of SK-channel inhibition in humans.

Keyphrases

atrial fibrillation
catheter ablation
endothelial cells
left atrial
heart failure
oral anticoagulants
left atrial appendage
induced pluripotent stem cells
clinical trial
percutaneous coronary intervention
risk assessment
pluripotent stem cells
human health
coronary artery disease