High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase 2 Trial.
Channing J PallerMarianna L ZahurakAdel MandlNicole A MetriAliya LaljiElisabeth I HeathWilliam Kevin KellyChristopher J HoimesPedro C BarataJason TakseyDominique A GarrisonKartick PatraGinger L MilneNicole M AndersJulie M NaurothJennifer N DurhamCatherine Handy MarshallMark C MarkowskiMario A EisenbergerEmmanuel S AntonarakisMichael A CarducciSamuel R DenmeadeMark LevinePublished in: Cancer research communications (2024)
In this patient population, combining HDIVC with docetaxel did not improve PSA response, toxicity, or other clinical outcomes compared to docetaxel alone. Findings do not support the routine use of HDIVC in mCRPC treatment outside of clinical trials.