Mannose-binding lectin gene sequence data in Kelantan population.
Muhamad Aidil ZahidinNoor Haslina Mohd NoorMuhammad Farid JohanAbu Dzarr AbdullahZefarina ZulkafliHisham Atan EdinurPublished in: Scientific data (2024)
The human mannose-binding lectin (MBL) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. Despite this significance, gene studies concerning MBL sequencing are uncommon in Malaysia. Therefore, we aimed to preliminary described the human MBL sequencing dataset based on the Kelantan population. Blood samples were collected from 30 unrelated individuals and underwent DNA extraction, genotyping, and sequencing. The sequencing data generated 886 bp, which were deposited in GenBank (ON619541-ON619546). Allelic variants were identified and translated into six MBL haplotypes: HYPA, HYPB, LYPB, LXPB, HXPA, and LXPA. An evolutionary tree was constructed using the haplotype sequences. These findings contribute to the expansion of MBL information within the country, providing a valuable baseline for future research exploring the association between the gene and targeted diseases.
Keyphrases
- copy number
- genome wide
- immune response
- endothelial cells
- single cell
- infectious diseases
- genome wide identification
- pluripotent stem cells
- electronic health record
- dna methylation
- multiple sclerosis
- high throughput
- wastewater treatment
- machine learning
- big data
- toll like receptor
- gene expression
- drug delivery
- single molecule
- dna binding
- circulating tumor
- deep learning
- cord blood
- genetic diversity
- case control