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Brain structure in juvenile-onset Huntington disease.

Alexander TereshchenkoVincent MagnottaEric EppingKatherine MathewsPatricia Espe-PfeiferErin MartinJeffrey DawsonWenzhen DuanPeg Nopoulos
Published in: Neurology (2019)
The primary pathology of JOHD extends beyond changes in the striatal volume. Brain morphology in both mice and human patients with JHD shows proportional cerebellar enlargement. This pattern of brain changes may explain the unique picture of hypokinetic motor symptoms in JHD, which is not seen in the hyperkinetic chorea-like phenotype of adult-onset HD.
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