Antimicrobial Treatment of Serratia marcescens Invasive Infections: Systematic Review.
Radica Zivkovic ZaricMilan ZaricMarija SekulicNenad ZornicJelena NesicVesna Z RosicTatjana VulovicMarko SpasicMarko VuletaJovan JovanovicDalibor JovanovicStefan JakovljevicPetar CanovicPublished in: Antibiotics (Basel, Switzerland) (2023)
Background : Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. According to the literature, S. marcescens is resistant to a wide range of antibiotics, including penicillin, cephalosporin, tetracycline, macrolide, nitrofurantoin, and colistin. We conducted a systematic review of published reports, determined what invasive infections could cause SM, and established the most appropriate antibiotic therapy. Methods : We registered this systematic review on the PROSPERO registry of systematic reviews-meta-analyses before we started our research (registration number CRD42022323159). The online searches of published studies were implemented via MEDLINE, the Cochrane Central Register of Controlled Trials, EBSCO, Scopus, Google Scholar, SCIndex, and the registry of clinical studies of human participants (ClinicalTrials.gov). Results : Our study included 32 published articles (9 case series and 23 case reports). There were 57 individual cases, respectively. The oldest patient was 97 years and the youngest patient was a newborn. S. marcescens was, in most cases, isolated from blood followed by urine and cerebrospinal fluid. In most cases, sensitivity was tested to cotrimoxazole (from 27 isolates, 10 showed resistance) followed by gentamicin (from 26 isolates, 3 showed resistance) as well as amikacin (from 21 isolates, none showed resistance). Patients died from an infection in 21 cases (31%). Conclusions : Treatment of SM infections should include carbapenems or aminoglycosides in combination with third-generation (and eventually fourth-generation) cephalosporin. Cotrimoxazole should be considered in cases of uncomplicated urinary infections.
Keyphrases
- meta analyses
- systematic review
- gram negative
- multidrug resistant
- case report
- randomized controlled trial
- cerebrospinal fluid
- end stage renal disease
- staphylococcus aureus
- drug resistant
- ejection fraction
- genetic diversity
- endothelial cells
- healthcare
- prognostic factors
- escherichia coli
- acinetobacter baumannii
- replacement therapy
- peritoneal dialysis
- smoking cessation
- combination therapy
- mesenchymal stem cells
- case control