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Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm.

Huy M DaoKhaled AboulFotouhAasim Faheem HussainAlexander E MarrasKeith P JohnstonZhengrong CuiRobert O Williams
Published in: Pharmaceutical research (2024)
Analyzing SAXS profiles based on DENSS algorithm to yield a reconstructed electron density based three-dimensional model can be a useful physicochemical characterization method in the toolbox to study mRNA-LNPs and facilitate their development.
Keyphrases
  • machine learning
  • high resolution
  • deep learning
  • electron microscopy
  • binding protein
  • magnetic resonance imaging
  • fatty acid
  • magnetic resonance
  • mass spectrometry
  • electron transfer