HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA.
Eric LeungKathy HanJinfeng ZouZhen ZhaoYangqiao ZhengTing Ting WangAriana RostamiLillian L SiuTrevor J PughScott V BratmanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
HPV-seq is a quantitative method for ctDNA detection that outperforms dPCR and reveals qualitative information about ctDNA. Our findings in this proof-of-principle study could have implications for treatment monitoring of disease burden in HPV-related cancers. Future prospective studies are needed to confirm that patients with undetectable HPV ctDNA following chemoradiotherapy have exceptionally high cure rates.
Keyphrases
- circulating tumor
- high grade
- cell free
- circulating tumor cells
- cervical cancer screening
- single cell
- label free
- systematic review
- loop mediated isothermal amplification
- high resolution
- squamous cell carcinoma
- gene expression
- rectal cancer
- radiation therapy
- mass spectrometry
- young adults
- current status
- sensitive detection
- tandem mass spectrometry
- molecularly imprinted