Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment?
Sebastian BrandnerSarah SchroeterGürsel ÇalışkanSeda SalarKatja KobowRoland CorasIngmar BlümckeHajo M HamerMichael SchwarzMichael BuchfelderAnna MaslarovaPublished in: Epilepsia (2021)
Our results show a direct negative glucocorticoid effect on synaptic potentiation in the human cortex and imply chronic activation of GRs. Chronic stress may therefore contribute to memory impairment in patients with temporal lobe epilepsy. Furthermore, the activity-dependent acute inhibitory effect of dexamethasone suggests a mechanism of synaptic downscaling by which postictally increased cortisol levels may prevent pathologic plasticity upon seizures.
Keyphrases
- temporal lobe epilepsy
- endothelial cells
- end stage renal disease
- newly diagnosed
- drug induced
- induced pluripotent stem cells
- working memory
- functional connectivity
- chronic kidney disease
- liver failure
- pluripotent stem cells
- low dose
- prognostic factors
- high dose
- stress induced
- intensive care unit
- extracorporeal membrane oxygenation
- heat stress
- rectal cancer