Investigation of the anti-pseudorabies virus activity of interferon lambda 3 in cultured porcine kidney epithelial cells.

Huidan DengZhijie JianLing ZhuFengqin LiJun ZhaoJunliang DengXiangang SunZhiwen Xu

Published in: Veterinary medicine and science (2022)

IFN-λ3 had antiviral activity against PRV and the upregulation of ISGs and IFN-γ mRNA expression may be the mechanism of IFN-λ3's antiviral activities. Thus, IFN-λ3 has a decisive function that greatly limits PRV replication in PK-15 cells. Our study explores the antiviral activity of IFN-λ3 on PRV for the first time.

Keyphrases

dendritic cells
immune response
induced apoptosis
poor prognosis
endothelial cells
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
long non coding rna
pi k akt