Bone marrow niche chemoprotection of metastatic solid tumors mediated by CYP3A4.
Gabriel GhiaurKenneth C ValkenburgChristopher EstebAlexander AmbinderPhilip H ImusKenneth J PientaRichard J JonesPublished in: Cancer (2023)
These results suggest that, similar to observations from hematologic malignancies, the BM microenvironment, through expression of CYPs, creates a sanctuary site from chemotherapy for metastatic solid tumors. Targeting these sanctuaries holds promise for eradicating bone metastasis in solid tumors.
Keyphrases
- bone marrow
- squamous cell carcinoma
- small cell lung cancer
- poor prognosis
- mesenchymal stem cells
- stem cells
- locally advanced
- bone mineral density
- cancer therapy
- big data
- soft tissue
- machine learning
- drug delivery
- radiation therapy
- bone loss
- long non coding rna
- postmenopausal women
- artificial intelligence
- rectal cancer
- deep learning
- chemotherapy induced