Enhanced effect of human mesenchymal stem cells expressing human TNF-αR-Fc and HO-1 gene on porcine islet xenotransplantation in humanized mice.
Han Sin LeeSanghyun SongDu Yeon ShinGeun-Soo KimJong-Hyun LeeChan Woo ChoKyo Won LeeHyojun ParkCurie AhnJaeseok YangHeung-Mo YangJae Berm ParkSung-Joo KimPublished in: Xenotransplantation (2017)
Our results suggest that HO-1/sTNF-αR-MSCs are efficient tools for porcine islet xenotransplantation, and this study may provide basic information for pre-clinical animal models and future clinical trials of porcine islet xenotransplantation.
Keyphrases
- mesenchymal stem cells
- endothelial cells
- clinical trial
- induced pluripotent stem cells
- umbilical cord
- rheumatoid arthritis
- stem cells
- randomized controlled trial
- genome wide
- bone marrow
- pi k akt
- gene expression
- transcription factor
- social media
- high fat diet induced
- open label
- genome wide identification
- monoclonal antibody
- genome wide analysis