The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis.
Maitray A PatelDouglas D FraserMark J DaleyGediminas CepinskasNoemi VeraldiSerge GrazioliPublished in: Molecular medicine (Cambridge, Mass.) (2024)
The plasma proteome of MIS-C patients was distinct from that of SCNS. The key proteins demonstrated expression in all organ systems and most cell types. The unique proteomic signature identified in MIS-C patients could aid future diagnostic and therapeutic advancements, as well as predict hospital length of stays, interventions, and mortality risks.
Keyphrases
- end stage renal disease
- sars cov
- newly diagnosed
- chronic kidney disease
- ejection fraction
- healthcare
- physical activity
- oxidative stress
- intensive care unit
- poor prognosis
- cardiovascular disease
- acute kidney injury
- coronary artery disease
- cardiovascular events
- type diabetes
- single cell
- case report
- mesenchymal stem cells
- cell therapy
- climate change
- adverse drug
- septic shock