Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities.
Álvaro López-JaneiroEduardo Miraval WongDaniel Jiménez-SánchezCarlos Ortiz de SolorzanoMaria D LozanoAlvaro TeijeiraKurt A SchalperIgnacio Melero BermejoCarlos E De AndreaPublished in: Journal for immunotherapy of cancer (2024)
In this review, we cover standard techniques as well as new advances in the field of spatial analysis of the immune microenvironment. We focused on marker quantification, spatial intratumor heterogeneity analysis, cell‒cell spatial interaction studies and neighborhood analyses.