Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model.
Susana Aideé González-ChávezSalma Marcela López-LoezaSamara Acosta-JiménezRubén Cuevas-MartínezCésar Pacheco-SilvaEduardo Chaparro-BarreraCesar Francisco Pacheco TenaPublished in: Biomolecules (2023)
Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applied at the disease's preclinical phase on the joints of DBA/1 mice with collagen-induced arthritis (CIA). Twelve mice with CIA were randomly distributed into two groups: the CIA-Ex group, which undertook treadmill PE, and the CIA-NoEx, which was not exercised. The effects of PE were evaluated through clinical, histological, transcriptomics, and immunodetection analyses in the mice's hind paws. The CIA-Ex group showed lower joint inflammation and damage and a decreased expression of RA-related genes ( Tnf Il2 , Il10 , Il12a , IL23a , and Tgfb1 ) and signaling pathways (Cytokines, Chemokines, JAK-STAT, MAPK, NF-kappa B, TNF, and TGF-beta). TNF-α expression was decreased by PE in the inflamed joints. Low-intensity PE in pre-arthritic CIA reduced the severity through joint down-expression of proinflammatory genes and proteins. Knowledge on the underlying mechanisms of PE in preclinical arthritis and its impact on reducing the risk of developing RA is still needed.
Keyphrases
- rheumatoid arthritis
- disease activity
- oxidative stress
- signaling pathway
- poor prognosis
- ankylosing spondylitis
- interstitial lung disease
- cell therapy
- high fat diet induced
- end stage renal disease
- healthcare
- nuclear factor
- newly diagnosed
- diabetic rats
- chronic kidney disease
- metabolic syndrome
- binding protein
- ejection fraction
- adipose tissue
- stem cells
- dna methylation
- epithelial mesenchymal transition
- physical activity
- peritoneal dialysis
- neural network
- induced apoptosis
- endothelial cells
- mesenchymal stem cells
- bone marrow
- skeletal muscle
- type diabetes
- cell proliferation