Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.
Farshad NassiriAnkur ChakravarthyShengrui FengShu Yi ShenRomina NejadJeffrey A ZuccatoMathew R VoisinVikas PatilCraig HorbinskiKenneth AldapeGelareh ZadehDaniel D De CarvalhoPublished in: Nature medicine (2020)
Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that share cell-of-origin lineages and can be challenging to distinguish using standard-of-care imaging.
Keyphrases
- minimally invasive
- dna methylation
- end stage renal disease
- genome wide
- coronary artery bypass
- optic nerve
- single cell
- chronic kidney disease
- ejection fraction
- healthcare
- peritoneal dialysis
- high resolution
- surgical site infection
- prognostic factors
- squamous cell carcinoma
- cell therapy
- pain management
- locally advanced
- coronary artery disease
- optical coherence tomography
- patient reported
- loop mediated isothermal amplification
- atrial fibrillation