Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity.
Kikumi D Ono-MooreLing ZhaoShurong HuangJeonga KimJennifer M RutkowskyRyan G SnodgrassDina A SchneiderMichael J QuonJames L GrahamPeter J HavelDaniel H HwangPublished in: Immunity, inflammation and disease (2017)
Together, these results suggest that constitutively active TLR4-induced inflammation in white adipose tissue is not sufficient to induce systemic insulin resistance, and that high fat diet-induced insulin resistance may require other signals in addition to TLR4-mediated inflammation.
Keyphrases
- insulin resistance
- high fat diet induced
- adipose tissue
- toll like receptor
- inflammatory response
- high fat diet
- metabolic syndrome
- oxidative stress
- immune response
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- diabetic rats
- poor prognosis
- nuclear factor
- high glucose
- gene expression
- glycemic control
- drug induced
- long non coding rna
- binding protein
- endothelial cells