A pediatric regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: Results of the ALLRE08 PETHEMA trial.

Josep-María RiberaMireia MorgadesPau MontesinosMar TormoDaniel Martínez-CarballeiraJosé González-CamposCristina GilPere BarbaRaimundo García-BoyeroRosa CollMaría PedreñoJordi RiberaSantiago MercadalSusana VivesAndrés NovoEulàlia GenescàJesús-María Hernández-RivasJuan BerguaMaría-Luz AmigoFerran Vall-LloveraPilar Martínez-SánchezMaría CalbachoIrene García-CadenasAntoni Garcia-GuiñonMaría-José Sánchez-SánchezMarta CerveraEvarist FeliuAlberto Orfaonull null

Published in: Cancer medicine (2020)

A full pediatric trial is feasible and effective for AYA with Ph-neg, SR-ALL, with better results for adolescents than for YA. Outcome of patients with poor early response rescued with a HR trial was not significantly inferior.

Keyphrases

acute lymphoblastic leukemia
phase iii
study protocol
phase ii
clinical trial
young adults
randomized controlled trial
physical activity
allogeneic hematopoietic stem cell transplantation
open label
dna methylation
genome wide