Transcriptomic Profiling of Peripheral B Cells in Antibody Positive Sjogren's Patients Reveals Interferon Signature.
Mehrnaz Maleki-FischbachKelsey AndersonEvans R Fernández PérezPublished in: Genes (2024)
We found upregulated expression of type-I and type-II interferon (IFN)-induced genes, as well as genes that may contribute to other concomitant conditions, including infections and a higher risk of myeloproliferative disorders. This adds insight into the autoimmune process and suggests potential targets for future functional and prognostic studies.
Keyphrases
- dendritic cells
- end stage renal disease
- genome wide
- ejection fraction
- newly diagnosed
- single cell
- poor prognosis
- chronic kidney disease
- immune response
- multiple sclerosis
- prognostic factors
- peritoneal dialysis
- drug induced
- genome wide identification
- bioinformatics analysis
- gene expression
- current status
- rna seq
- dna methylation
- oxidative stress
- human health