Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
Nicholas F FitzCody M WolfeBrittany E PlaysoRichard J BiedrzyckiYi LuKyong Nyon NamIliya LefterovRadosveta KoldamovaPublished in: Molecular neurodegeneration (2020)
Our data demonstrate that lack of Trem2 differentially impacts the phenotype and brain transcriptome of APP mice expressing human APOE isoforms. The changes probably reflect the different effect of APOE isoforms on amyloid deposition.