Hepatic Fat-Genetic Risk Score Predicts Hepatocellular Carcinoma in Patients With Cirrhotic HCV Treated With DAAs.

Elisabetta Degasperi Enrico GalmozziSerena PelusiRoberta D'AmbrosioRoberta SoffrediniMarta BorghiRiccardo PerbelliniFloriana FacchettiMassimo IavaroneAngelo SangiovanniLuca Vittorio Valenti Pietro Lampertico

Published in: Hepatology (Baltimore, Md.) (2020)

In a large cohort of DAA-treated patients with cirrhotic HCV, GRS was associated with de novo HCC independently of classical risk factors, including liver disease severity. These data suggest that hepatic fat (i.e., lipotoxicity) promotes HCC in this setting and may represent a target for chemoprevention. Combination of clinical and genetic predictors may improve HCC risk stratification.

Keyphrases

hepatitis c virus
risk factors
adipose tissue
genome wide
copy number
fatty acid
human immunodeficiency virus
electronic health record
newly diagnosed
big data
gene expression
dna methylation
machine learning
artificial intelligence
deep learning