Efficacy of 12 weeks oral beta-alanine supplementation in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled trial.

Jana de BrandtWim DeraveFrank VandenabeelePascal PomièsLaura BlancquaertCharly KeytsmanMarina S Barusso-GrüningerFabiano F de LimaMaurice HayotMartijn A SpruitChris Burtin

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Beta-alanine supplementation is efficacious in augmenting muscle carnosine (+54% from mean baseline value) without side effects in patients with COPD in comparison with PL. However, accompanied beneficial changes in exercise capacity, quadriceps function, and muscle oxidative/carbonyl stress were not observed.

Keyphrases

double blind
skeletal muscle
chronic obstructive pulmonary disease
placebo controlled
open label
high intensity
clinical trial
phase iii
physical activity
lung function
study protocol
randomized controlled trial
resistance training
stress induced
gestational age
heat stress