A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value.

Natacha Entz-WerléLaetitia PoidevinPetr V NazarovOlivier PochBenoit LhermitteMarie Pierre ChenardHélène Burckel Amelia-Naomie SaboQuentin FuchsDavid CastelGeorges NoelLaurence Choulier Monique Dontenwill Eric Van Dyck

Published in: Cancers (2021)

We provide evidence that PARP1 overexpression, associated to XRCC1 expression, TP53 mutations, and TOP2A amplification, is a new theranostic and potential therapeutic target.

Keyphrases

dna repair
cell cycle
high grade
gene expression
cell proliferation
dna damage
low grade
poor prognosis
dna damage response
dna methylation
photodynamic therapy
nucleic acid
transcription factor
fluorescence imaging
human health
risk assessment
oxidative stress
climate change
iron oxide