Expression of MAGE-A and NY-ESO-1 cancer/testis antigens is enriched in triple-negative invasive breast cancers.
Ashwini RaghavendraPriyakshi Kalita-de CroftAna Cristina VargasChanel E SmartPeter T SimpsonJodi Marie SaunusSunil R LakhaniPublished in: Histopathology (2018)
MAGE-A and NY-ESO-1 are frequently expressed in TN breast cancer (~47% and 17% of TN cases, respectively), suggesting that targeting them could be feasible in this patient group. Expression is reasonably homogeneous in positive cases, suggesting that immunohistochemical analysis of tissue biopsies would be a reliable companion biomarker.