Valproic acid ameliorates cauda equina injury by suppressing HDAC2-mediated ferroptosis.

Qingjie KongFudong LiKaiqiang SunXiaofei SunJun Ma

Published in: CNS neuroscience & therapeutics (2023)

HDAC2 is critically involved in the ferroptosis and neuroinflammation in cauda equina injury, and VPA ameliorated cauda equina injury by suppressing HDAC2-mediated ferroptosis.

Keyphrases

cell death
histone deacetylase
traumatic brain injury
mouse model
lipopolysaccharide induced
cognitive impairment
inflammatory response