Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.
Arif KhanFahad A AlhumaydhiAmeen S S AlwashmiKhaled S AllemailemMohammed A AlsahliFaris A AlrumaihiAhmad Abdulaziz A AlmatroudiMugahid A MobarkAyman M MousaMasood Alam KhanPublished in: Journal of inflammation research (2020)
The findings of the present study indicated that DAS-induced apoptosis is strongly associated with the downregulation of FASN in tumor tissues. To the best of our knowledge, this is the first study that describes the role of FASN in BaP-induced lung carcinogenesis.