Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.

Dan-Qian ChenXia-Qing WuLin ChenHe-He HuYan-Ni WangYing-Yong Zhao

Published in: Therapeutic advances in chronic disease (2020)

PAA as a modulator of TPH-1 expression attenuated renal fibrosis through regulating the Wnt/β-catenin signaling pathway by acting on the protein stability of β-catenin and β-catenin-mediated transcription. TPH-1 was required for PAA to exert anti-fibrosis.

Keyphrases

cell proliferation
epithelial mesenchymal transition
poor prognosis
binding protein
transcription factor
stem cells
protein protein
signaling pathway
amino acid
long non coding rna
small molecule