Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis.

Aaron R FroeseChiko ShimboriPierre-Simon BellayeMark InmanSteffen ObexSafoora FatimaGisli JenkinsJack GauldieKjetil AskMartin Kolb

Published in: American journal of respiratory and critical care medicine (2017)

Mechanical tissue stretch contributes to the development of pulmonary fibrosis via mechanotransduced activation of TGF-β1 in rodent and human pulmonary fibrosis.

Keyphrases

pulmonary fibrosis
transforming growth factor
epithelial mesenchymal transition
endothelial cells
high glucose
diabetic rats
induced pluripotent stem cells
pluripotent stem cells
signaling pathway