Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration.
Anurima MajumderSina HosseinianMia StroudEmma AdhikariJames J SallerMatthew A SmithGuolin ZhangShruti AgarwalMarc CreixellBenjamin S MeyerFumi KinoseKiah BowersBin FangPaul Allen StewartEric A WelshTheresa A BoyleAaron S MeyerJohn M KoomenEric B HauraPublished in: Molecular cancer research : MCR (2022)
Our study defines mechanisms of action of AXL in lung cancers which can be used to establish assays to measure drug targetable active AXL complexes in patient tissues and inform the strategy for targeting it's signaling as an anticancer therapy.