Deep brain stimulation of globus pallidus internus and subthalamic nucleus in Parkinson's disease: a multicenter, retrospective study of efficacy and safety.

Michele MainardiDario CipriettiManuela PilleriGiulia BonatoLuca WeisValeria CianciRoberta BiundoFlorinda FerreriMassimo PiacentinoAndrea LandiAndrea GuerraAngelo Antonini

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)

Both STN-DBS and GPi-DBS are effective in improving motor symptoms severity and complications, but GPi-DBS has a greater impact on motor fluctuations and motor experiences of daily living. These results suggest that the two targets should be considered equivalent in motor efficacy, with GPi-DBS as a valuable option in patients with prominent motor complications. The occurrence of suicides in STN-treated patients claims further attention in target selection.

Keyphrases

deep brain stimulation
parkinson disease
obsessive compulsive disorder
end stage renal disease
newly diagnosed
chronic kidney disease
risk assessment
ejection fraction
risk factors
clinical trial
cross sectional
health insurance