Genome-wide DNA methylation analysis identifies potent CpG signature for temzolomide response in non-G-CIMP glioblastomas with unmethylated MGMT promoter: MGMT-dependent roles of GPR81.

Bao-Bao LiangYu-Hong WangJing-Jing HuangShuai LinGuo-Chao MaoZhang-Jian ZhouWan-Jun YanChang-You ShanHui-Zi WuAmandine EtcheverryYa-Long HeFang-Fang LiuHua-Feng KangAn-An YinShu-Qun Zhang

Published in: CNS neuroscience & therapeutics (2023)

The 64 TMZ efficacy-related CpGs and in particular the 10-CpG risk signature may serve as promising predictive biomarker candidates for guiding optimal usage of TMZ in G-CIMP-/unMGMT GBMs.

Keyphrases

dna methylation
genome wide
gene expression
copy number
fatty acid