Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities.
Shuhei AgawaSeiji FutagamiHiroshi YamawakiRina TsushimaKazutoshi HiguchiMayu HabiroRie KawawaYasuhiro KodakaNobue UekiYoshiyuki WatanabeKatya GudisRhuji OhashiKatsuhiko IwakiriPublished in: PloS one (2022)
Elevated trypsin levels might be partly associated with duodenal inflammatory responses through PAR2-related degranulated eosinophils and the reduction of occludin in patients with ECP and FD-P.