PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3.

Amata Amy SorianoTiziana de CristofaroTina Di PalmaSerena DotoloPriyanka GokulnathAntonella IzzoGaetano CalìAngelo FacchianoMariastella Zannini

Published in: Cancer cell international (2019)

Our results demonstrate that PAX8 modulates the interaction of tumor cells with the extracellular matrix (ECM). Notably, we also highlight a novel pathway downstream this transcription factor. Overall, PAX8 could be a potential therapeutic target for high-grade serous carcinoma.

Keyphrases

high grade
extracellular matrix
low grade
transcription factor
poor prognosis
dna binding
risk assessment
cell migration