Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis.
Abeer H ObaidChryssa ZografouDouangsone D VadysirisackBailey Munro-SheldonMiriam L FichtnerBhaskar RoyWilliam M PhilbrickJeffrey L BennettRichard J NowakKevin C O'ConnorPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
A novel assay for evaluating AChR autoantibody-mediated complement activity was developed. A subset of patients that lacks association between MAC formation and autoantibody binding or disease burden was identified. The assay may provide a better understanding of the heterogeneous autoantibody molecular pathology and identify patients expected to benefit from complement inhibitor therapy.