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Cell Death Induced by the Combination of Ephedra sinica Extract and Radiation in HNSCC is Positively Related to BAX and p-MLKL Expression.

Seon Rang WooJoo Kyung NohSun-Young AhnMin Kyeong LeeHyeon Seo YuSoonki MinMoonkyoo KongJung Woo LeeYoung Chan LeeSeong-Gyu KoYoung Gyu Eun
Published in: Anti-cancer agents in medicinal chemistry (2023)
ES extract demonstrated significant cytotoxic potential in HNSCC cells without affecting normal cells. It enhanced the radiosensitivity of HNSCC cells by upregulating BAX and p-MLKL expression, leading to increased cell death. These results suggest ES extract exhibits a potential radiosensitizing capacity in HNSCC.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • oxidative stress
  • endoplasmic reticulum stress
  • poor prognosis
  • signaling pathway
  • radiation therapy
  • radiation induced