Cell Death Induced by the Combination of Ephedra sinica Extract and Radiation in HNSCC is Positively Related to BAX and p-MLKL Expression.

Seon Rang WooJoo Kyung NohSun-Young AhnMin Kyeong LeeHyeon Seo YuSoonki MinMoonkyoo KongJung Woo LeeYoung Chan LeeSeong-Gyu KoYoung Gyu Eun

Published in: Anti-cancer agents in medicinal chemistry (2023)

ES extract demonstrated significant cytotoxic potential in HNSCC cells without affecting normal cells. It enhanced the radiosensitivity of HNSCC cells by upregulating BAX and p-MLKL expression, leading to increased cell death. These results suggest ES extract exhibits a potential radiosensitizing capacity in HNSCC.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
oxidative stress
endoplasmic reticulum stress
poor prognosis
signaling pathway
radiation therapy
radiation induced