From registration to publication: A study on Dutch academic randomized controlled trials.
Joost HuiskensBoudewijn R J KoolJean-Michel BakkerEmma R J BrunsStijn W de JongePim B OlthofBelle V van RosmalenThomas M van GulikLotty HooftCornelis J A PuntPublished in: Research synthesis methods (2020)
This study shows that approximately one out of four Dutch investigator-initiated RCTs remains unpublished 5 years after initiation. The observed low overall consistency with the initial study outline is a matter of concern and warrants improvements in trial design and assessment of trial feasibility.