Blocking GPR15 counteracts integrin-dependent T cell gut homing in vivo.

Sebastian SchrammLi-Juan LiuMarek SaadLisa DietzMark DeddenTanja M MüllerImke AtreyaCaroline J VoskensGisela FeltenMarkus F NeurathSebastian Zundler

Published in: Journal of Crohn's & colitis (2024)

GPR15 seems to have a broad, but organ-selective impact on T cell trafficking and is therefore a promising target for future therapy of IBD. Further studies are needed.

Keyphrases

fatty acid
current status
stem cells
cell adhesion
bone marrow
smoking cessation