CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid-derived suppressor cells.

Haitao GuWensheng DengZhong ZhengKe WuFeng Sun

Published in: Immunity, inflammation and disease (2021)

Our study indicates that PDAC cells produced CCL2, which promoted localized M-MDSC recruitment and immune suppression, thereby promoting tumor progression.

Keyphrases

induced apoptosis
cell cycle arrest
liver injury
oxidative stress
poor prognosis
signaling pathway
cell proliferation
drug induced