Correlation of plasma metabolites with glucose and lipid fluxes in human insulin resistance.
Annick V HartstraPieter F de GrootDiogo Mendes BastosEvgeni LevinMireille J SerlieMaarten R SoetersCeyda T PekmezLars O DragstedMariette T AckermansAlbert K GroenMax NieuwdorpPublished in: Obesity science & practice (2020)
This approach revealed a number of plasma metabolites that correlated reasonably well with glycemic and lipolytic flux parameters, measured using gold standard techniques. These metabolites may be used to predict the rate of glucose disposal in humans with obesity to a similar extend as HOMA, thus providing potential novel biomarkers for insulin resistance.