Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.

Hailong YuXiang CaoWei LiPinyi LiuYuanyuan ZhaoLilong SongJian ChenBeilei ChenWenkui YuYun Xu

Published in: Journal of neuroinflammation (2020)

This study provides new insight into potential treatment strategies for ICH injury involving astroglial Cx43 and Cx43Hcs. Suppression of abnormal astroglial Cx43 expression and Cx43Hc opening by Gap19 has anti-inflammatory and neuroprotective effects after ICH injury.

Keyphrases

anti inflammatory
poor prognosis
brain injury
binding protein
human health
climate change