Astrogliosis and compensatory neurogenesis after the very first ethanol binge drinking-like exposures in adolescent rat.

Our findings demonstrate that the cognitive deficits associated with hippocampal synaptic plasticity alterations that we previously characterized 48h after the very first binge-like exposures are associated with hippocampal structural plasticity, astrogliosis and decreased neuronal TLR4 expression, but not with microglia reactivity.