Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells.

Camilla U NiklassonElina FredlundEmanuela MonniJessica M LindvallZaal KokaiaEmma U HammarlundMarianne E BronnerSofie Mohlin

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)

Taken together, these results suggest that expression levels of HIF-2α must be strictly controlled during normal trunk neural crest development and that dysregulated levels affects several important features connected to stemness, migration, and development.

Keyphrases

induced apoptosis
stem cells
poor prognosis
signaling pathway
lower limb
endothelial cells
oxidative stress
binding protein
cell death
endoplasmic reticulum stress